Journal
NATURE REVIEWS IMMUNOLOGY
Volume 13, Issue 3, Pages 190-198Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3386
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Funding
- US National Institutes of Health [R01 HL097700, DK056638, HL097819, HL116340, HL069438]
- German Academic Exchange Service (DAAD)
- Japan Society for the Promotion of Science
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Circadian rhythms, which have long been known to play crucial roles in physiology, are emerging as important regulators of specific immune functions. Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also help to promote tissue recovery and the clearance of potentially harmful cellular elements from the circulation. This Review summarizes the current knowledge of circadian rhythms in the immune system and provides an outlook on potential future implications.
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