Journal
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
Volume 16, Issue 1, Pages 17-21Publisher
KOREAN SOC PEDIATRIC GASTROENTEROLOGY & NUTRITION
DOI: 10.5223/pghn.2013.16.1.17
Keywords
Microbiota; Inflammatory bowel diseases; Child
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The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a genetic predisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of dysbiosis, with alterations of the gut microbial composition, has been observed in patients with IBD. In this article, the author review recent studies of gut microbiota in IBD, particularly the importance of the gut microbiota in the pathogenesis of pediatric IBD.
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