Journal
POLYMER INTERNATIONAL
Volume 67, Issue 6, Pages 747-754Publisher
WILEY
DOI: 10.1002/pi.5566
Keywords
poly(p-phenylene vinylene); transdermal drug delivery; iontophoretic; ibuprofen; natural rubber; drug permeation
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Funding
- Conductive and Electroactive Polymers Research Unit of Chulalongkorn University
- Thailand Research Fund (TRF, TRF-Rubber Project)
- Royal Thai Government
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A flexible, natural rubber (NR) patch was developed for electrically controllable transdermal drug delivery. NR latex was crosslinked at various crosslinking ratios under the UV curing method. Ibuprofen (Ibu) was the model drug and was used as the dopant for poly(p-phenylene vinylene) (PPV) acting as the drug encapsulating host. For the pristine Ibu-loaded NR patch, the amount of lbu permeation increased with decreasing crosslink density and increasing electrical potential. For the lbu-doped PPV/NR patch, the amount of Ibu release permeation also increased with increasing electrical potential and was higher than that of the pristine NR matrices. Without an applied electric field, the drug remained attached to the PPV during an initial period of 6 h. Under an applied electric field, the oxidation state of the conductive polymer was altered, the iontophoretic effect, pore formation in the NR matrix, expansion of the pore size in hair follicles and PPV chain expansion combined to increase the lbu release permeation amount. Thus, the flexible PPV/NR transdermal drug delivery patch was demonstrated to be effective in drug release permeation based on the strength of the electrical potential, the crosslinking density and the presence of PPV as the encapsulation host. (C) 2018 Society of Chemical Industry
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