Journal
POLYMER CHEMISTRY
Volume 9, Issue 25, Pages 3436-3449Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8py00730f
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Funding
- Thousand Talents Plan for Young Professionals
- National Natural Science Foundation of China [21704104, 81572766, 31771630]
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06S029]
- West Light Foundation of The Chinese Academy of Sciences [2016XBZG_XBQNXZ_B_003]
- Science and Technology Planning Project of Guangdong Province [2016A010103015]
- Science and Technology Program of Guangzhou [201707010094]
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The cyclodextrin (CD) based host-guest inclusion complexation between cyclodextrins (CDs) and guest moieties has inspired the fabrication of novel supramolecular hydrogels for biomedical applications. From a topology of view, this article reviews the recent developments of two kinds of CD-based supramolecular hydrogels and their applications in biomedical fields respectively. On one hand, supramolecular hydrogels derived from CD-based poly(pseudo)rotaxanes generally displayed thixotropic and reversible properties and have been extensively developed as injectable drug delivery systems. On the other hand, supramolecular hydrogels based on the host-guest interaction between CDs and small guest moieties generally exhibited stimuli-responsive behaviors, typically the release of therapeutic agents. The development of CD-based supramolecular hydrogels provides a new platform for the design of novel biomaterials.
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