Journal
PHARMACOLOGICAL REVIEWS
Volume 65, Issue 2, Pages 545-577Publisher
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/pr.111.005603
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Funding
- Canadian Institutes of Health Research (CIHR) [MOP-79354]
- Fonds de la Recherche en Sante du Quebec
- CIHR
- McGill-CIHR Drug Development Training Program
- Canadian Center of Excellence in Commercialization and Research
- Canada Foundation for Innovation
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G beta gamma subunits from heterotrimeric G proteins perform a vast array of functions in cells with respect to signaling, often independently as well as in concert with G alpha subunits. However, the eponymous term G beta gamma does not do justice to the fact that 5 G beta and 12 G gamma isoforms have evolved in mammals to serve much broader roles beyond their canonical roles in cellular signaling. We explore the phylogenetic diversity of G beta gamma subunits with a view toward understanding these expanded roles in different cellular organelles. We suggest that the particular content of distinct G beta gamma subunits regulates cellular activity, and that the granularity of individual G beta and G gamma action is only beginning to be understood. Given the therapeutic potential of targeting G beta gamma action, this larger view serves as a prelude to more specific development of drugs aimed at individual isoforms.
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