Paraoxonase 1: A better atherosclerotic risk predictor than HDL in type 2 diabetes mellitus

Introduction: Type 2 diabetes mellitus is a state of glycative stress and oxidative stress. Lower level of serum PON 1 has been correlated to higher morbidity and mortality related to cardiovascular complications in type 2 diabetes mellitus. Objectives: To estimate and compare the serum PON 1 levels in type 2 diabetes mellitus and controls and to predict which one is the better atherosclerotic risk predictor among HDL and PON 1 in T2DM patients. Materials and methods: An observational analytical case-control study was conducted with a sample size of 30 in two groups like group I (30 cases of type 2 diabetes mellitus diagnosed by ADA 2010 criteria) and group II (30 age and sex matched controls). Human serum paroxonase 1 levels were measured by ELISA. Results: Both HDL and PON 1 were negatively correlated with the various atherogenic indices (AIP, AC, CRI I, CRI II) but the strength of negative correlation is always greater for PON 1. In multiple linear regression analysis, we found that the regression coefficient (beta) is always higher for PON 1 than for HDL while taking the atherogenic indices as outcome variable. Conclusion: PON 1 can be a better predictor than HDL for atherosclerotic risk in type 2 diabetes mellitus. (C) 2013 Diabetes India. Published by Elsevier Ltd. All rights reserved.