Journal
PLATELETS
Volume 29, Issue 7, Pages 662-669Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/09537104.2018.1447660
Keywords
Adhesion; fibrin procoagulant; thrombus
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Funding
- Interreg Euregio Meuse Rhine programme, PolyValve
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In recent years, considerable progress has been made in understanding the mechanisms involved in platelet activation during hemostasis and thrombosis. Parallel-plate flow chambers and other microfluidic devices have markedly contributed to this insight. Conversely, such flow devices are now increasingly used to monitor the combined processes of platelet aggregation, thrombus formation, and coagulation in human blood. Currently, by combining microspotting and multi-color fluorescence microscopy, this technology offers the capability of high-throughput measurement of platelet activation processes, even in small blood samples. Here we review the potential of flow chamber devices for complex (multiparameter) platelet and coagulation phenotyping, focusing on patients with (genetic) platelet- or coagulation-based bleeding disorders as well as monitoring of antithrombotic medication. Animal studies are not discussed.
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