Journal
PLANT SCIENCE
Volume 273, Issue -, Pages 71-83Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.plantsci.2017.12.007
Keywords
Rubisco; Calvin cycle; Metabolic engineering; Synthetic biology; Photorespiration; Carboxylation; Formate assimilation
Categories
Funding
- Max Planck Society
- European Commission FET Open grant FutureAgriculture [686330]
- German Ministry of Education and Research grant FormatPlant
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Increasing agricultural productivity is one of the major challenges our society faces. While multiple strategies to enhance plant carbon fixation have been suggested, and partially implemented, most of them are restricted to relatively simple modifications of endogenous metabolism, i.e., low hanging fruit. Here, I portray the next generation of metabolic solutions to increase carbon fixation rate and yield. These strategies involve major rewiring of central metabolism, including dividing Rubisco's catalysis between several enzymes, replacing Rubisco with a different carboxylation reaction, substituting the Calvin Cycle with alternative carbon fixation pathways, and engineering photorespiration bypass routes that do not release carbon. While the barriers for implementing these elaborated metabolic architectures are quite significant, if we truly want to revolutionize carbon fixation, only daring engineering efforts will lead the way.
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