Journal
PLANT FOODS FOR HUMAN NUTRITION
Volume 73, Issue 1, Pages 13-17Publisher
SPRINGER
DOI: 10.1007/s11130-018-0653-6
Keywords
Glycaemic index; Amaranth; Quinoa; Chia; PPAR-gamma; Obesity; Type 2 diabetes
Funding
- MINECO [AGL2016-75687-C2-1-R]
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Bakery formulations limiting glucose availability for uptake without compromising product quality are required. Herein, bread formulations containing whole flour from Amaranthus hypochondriacus (AB), Chenopodium quinoa (QB), Salvia hispanica L (ChB) or wheat (WWB) were compared to white bread (WB) for glycaemic index (GI) in fasted animals. The hepatic expression (mRNA) of PPAR-gamma receptor as key regulator in substrate fractionation towards energy expenditure was monitored. GIs were associated to fluxes of glucose release (F-Gluc) and metabolic response (MTT assay) of HepG2 cells. ChB (19.7%) and AB (13.5%) decreased GI to a higher extent than QB (2.7%), but all increased expression of PPAR gamma in relation to WB. F-Gluc (AB > > ChB, WWB, WB > QB) showed a reciprocal relationship with the area under curve (AUC) in vivo, and decreased MTT conversion values (WB > WWB, ChB, AB, QB) by HepG2 cells. Thus, inclusion of latin-american crops (LAcs) reducing GI, without compromising bread quality, could help preventing metabolic diseases.
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