Journal
NATURE REVIEWS CANCER
Volume 13, Issue 5, Pages 365-U95Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3498
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Funding
- German Research Foundation [SFB832, SFB704, SPP 1590]
- German Cancer Aid SP9 in the German Melanoma Research Network
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Immunotherapies, signal transduction inhibitors and chemotherapies can successfully achieve remissions in advanced stage cancer patients, but durable responses are rare. Using malignant melanoma as a paradigm, we propose that therapy-induced injury to tumour tissue and the resultant inflammation can activate protective and regenerative responses that represent a shared resistance mechanism to different treatments. Inflammation-driven phenotypic plasticity alters the antigenic landscape of tumour cells, rewires oncogenic signalling networks, protects against cell death and reprogrammes immune cell functions. We propose that the successful combination of cancer treatments to tackle resistance requires an interdisciplinary understanding of these resistance mechanisms, supported by mathematical models.
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