Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial

Elevated levels of reactive oxygen species under diabetic condition lead to vascular complications and inflammation. This study aimed to examine the effects of hesperidin supplement on blood pressure and inflammatory markers in type 2 diabetes. In this research, 64 patients were randomly allocated to receive 500mg/day hesperidin or placebo capsules for 6weeks. Data on systolic blood pressure (SBP), diastolic blood pressure, serum total antioxidant capacity (TAC), tumor necrosis factor alpha, interleukin 6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) were collected at the baseline and at the end of the study. In the hesperidin group, SBP (122.7 +/- 8.5 vs. 119.0 +/- 7.4; p=.005), mean arterial blood pressure (94.2 +/- 5.5 vs. 91.8 +/- 5.5; p=.009), IL-6 (8.3 +/- 2.1 vs. 7.4 +/- 1.8; p=.001), and hs-CRP (1.9 +/- 1.2 vs. 1.1 +/- 0.9; p<.000) decreased whereas TAC increased (0.74 +/- 0.1 vs. 0.82 +/- 0.1; p<.000) in comparison to the baseline values. There was a significant difference in mean percent change of SBP, diastolic blood pressure, mean arterial blood pressure, serum TAC, and inflammatory markers (tumor necrosis factor alpha, IL-6, and hs-CRP) between hesperidin and control groups following intervention in adjusted models (p<.05). These results suggest that hesperidin may have antihypertensive and anti-inflammatory effects in type 2 diabetes.