Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp BCC47066

Eight new anthrone derivatives, which are (+)-oxanthromicins E (1), F (4), and G (5), (+/-)-hemi-oxanthromicin D (2), azanthromicin A (7), adxanthromicin A(2) (10), 3-methoxy oxanthromicin (11), and (+/-)-oxanthromicin G (13), along with eight previously described compounds (6, 8, 9, 12, 14-17) have been isolated from the terrestrial actinomycete, Actinomodura sp. BCC47066. The chemical structures have been determined on the basis of NMR spectroscopic information and chemical degradation. The configurations were assigned based upon CD spectral analyses, compared with the related compounds. Furthermore, the isolated compounds were assessed for biological activity. Compounds 10, 12, and 16 showed anti-Bacillus cereus with IC50 in a range of 1.56-12.50 mu g/mL, while compounds 10 and 12 exhibited anti-phytopathogenic activity against Colletotrichum capsici and C. gloeosporioides with equal IC50 value of 6.25 mu g/mL. All tested compounds possessed low cytotoxicity against both malignant and non-malignant cells.