Journal
PHYTOCHEMISTRY LETTERS
Volume 26, Issue -, Pages 50-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2018.05.019
Keywords
Pyridine derivatives; Sesquiterpenoid derivative; Fungal strain; Climacocystis montana; Cytotoxicity
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Funding
- Key research and development project of Anhui Province [1704a0802145]
- Natural Science Key Research Program of Anhui Province University [KJ2017A294, KJ2016A853]
- Public Welfare Technology Application Research Linkage Plan of Anhui Province [1501ld04001]
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Two new pyridine derivatives climacomontaninates A-B(1-2), and a new sesquiterpenoid derivative climacomontanetate (3), together with twelve known compounds (4-15) were isolated from the culture extract of the fungal strain Climacocystis montana from the root bark of Paeonia ostii. The structures of these compounds were determined through spectroscopic methods such as NMR and FIRMS. Moreover, we expound the absolute configuration of 1 using the organic synthesis method. The cytotoxicity against five human cancer cell lines of new compounds were evaluated by SRB assay.
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