Journal
PHYTOCHEMISTRY LETTERS
Volume 24, Issue -, Pages 110-113Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2018.01.020
Keywords
Khaya senegalensis; Mexicanolide-type Limonoids; Hydroxybutenolide; Anti-inflammatory; Cytotoxicity
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Funding
- National Natural Science Foundation of China [81573550, 31470416]
- Ph.D. Program Foundation of Ministry of Education of China [20120096130002]
- Outstanding Youth Fund of the Basic Research Program of Jiangsu Province [BK20160077]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R63]
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Four new mexicanolide-type limonoids with isomerized furan fragment khaysenelides G-J (1-4) were isolated from the stem barks of Khaya senegalensis. Their structures were elucidated on the basis of (1D and 2D) NMR and HRESIMS, and the normal furan rings in 1-4 were isomerized to hydroxybutenolide moieties. Bioactivities screening of new compounds indicated that 1 showed potent cytotoxicities against MDA-MB-231 and HepG2 human cancer cell lines with IC50 values of 6.02 and 8.98 mu M, and significant NO inhibitory activities in LPS-activated RAW 264.7 macrophages with IC50 values of 3.51 mu M.
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