Journal
PHYSIOLOGICAL REVIEWS
Volume 98, Issue 1, Pages 239-389Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00042.2016
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Funding
- National Institutes of Health (NIH)
- NIH
- Novo Nordisk
- Adelson Foundation
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS100366] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG048769, RF1AG057575] Funding Source: NIH RePORTER
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Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in morphological appearance; they express a multitude of receptors, channels, and membrane transporters. This complement underlies their remarkable adaptive plasticity that defines the functional maintenance of the CNS in development and aging. Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
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