Journal
PHYSIOLOGICAL REVIEWS
Volume 98, Issue 3, Pages 1335-1370Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00026.2017
Keywords
-
Categories
Funding
- U.S. National Institutes of Health Grants [HL122531, U10HL109172, U01HL108712, K08HL130540, T32HL7633-31, P01GM095467]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K08HL130540, U01HL108712, U10HL109172] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [F32AI134019] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM095467] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Airborne pathogens and environmental stimuli evoke immune responses in the lung. It is critical to health that these responses be controlled to prevent tissue damage and the compromise of organ function. Resolution of inflammation is a dynamic process that is coordinated by biochemical and cellular mechanisms. Recently, specialized proresolving mediators (SPMs) have been identified in resolution exudates. These molecules orchestrate anti-inflammatory and proresolving actions that are cell type specific. In this review, we highlight SPM biosynthesis, the influence of SPMs on the innate and adaptive immune responses in the lung, as well as recent insights from SPMs on inflammatory disease pathophysiology. Uncovering these mediators and cellular mechanisms for resolution is providing new windows into physiology and disease pathogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available