Journal
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Volume 23, Issue -, Pages 202-208Publisher
ELSEVIER
DOI: 10.1016/j.pdpdt.2018.06.019
Keywords
Mesoporous silica nanoparticles; Hybrid photosensitizer; Singlet oxygen; Antifungal photodynamic inactivation; Trichophyton rubrum
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Funding
- University of Cincinnati Technology Accelerator award
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Trichophyton rubrum is one of the most common dermatophytes, which can cause fungal nail and ringworm infections. Infections associated with T. rubrum have become a global phenomenon. Herein, we report the antifungal photodynamic inactivation of T. rubrum (ATCC 28188) using the mesoporous silica-coated silver nanoparticle-based hybrid photosensitizers without involving antifungal drugs. Results show that the hybrid photosensitizers display low cytotoxicity under the experimental conditions where significant killing (similar to 3 orders of magnitude) against T. rubrum is observed. These results demonstrate the potential applications of the nanoparticle-based hybrid photosensitizers in antifungal photodynamic therapy against T. rubrum.
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