Journal
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
Volume 34, Issue 1, Pages 60-68Publisher
WILEY
DOI: 10.1111/phpp.12368
Keywords
chemoprevention; drug delivery strategy; skin cancer; UVB radiation
Categories
Funding
- National Institute on Minority Health and Health Disparities (NIMHD) P20 program [IP20MD006738-03]
- Cancer Institute of the National Institutes of Health [R21CA175618]
- Moffitt Skin Cancer SPORE Special Cycle-Women and Minority Development Research Program(DRP) award [4P50CA168536]
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Annually, more skin cancer cases are diagnosed than the collective incidence of the colon, lung, breast, and prostate cancer. Persistent contact with sunlight is a primary cause for all the skin malignancies. UVB radiation induces reactive oxygen species (ROS) production in the skin which eventually leads to DNA damage and mutation. Various delivery approaches for the skin cancer treatment/prevention have been evolving and are directed toward improvements in terms of delivery modes, therapeutic agents, and site-specificity of therapeutics delivery. The effective chemoprevention activity achieved is based on the efficiency of the delivery system used and the amount of the therapeutic molecule deposited in the skin.In this article, we have discussed different studies performed specifically for the chemoprevention of UVB-induced skin cancer. Ultra-flexible nanocarriers, transethosomes nanocarriers, silica nanoparticles, silver nanoparticles, nanocapsule suspensions, microemulsion, nanoemulsion, and polymeric nanoparticles which have been used so far to deliver the desired drug molecule for preventing the UVB-induced skin cancer.
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