Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 17, Issue 11, Pages 1490-1514Publisher
SPRINGERNATURE
DOI: 10.1039/c8pp00008e
Keywords
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Funding
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant [764837]
- Science Foundation Ireland [IvP 13/IA/1894]
- Irish Research Council [GOIPG/2016/1250]
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Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable, suffers from poor selectivity and has fast decomposition rates in biological media. Across the scientific community, there is a conscious effort to refine singlet oxygen interactions and initiate selective and controlled release to produce a consistent and reproducible therapeutic effect in target tissue. This perspective aims to provide an insight into the contemporary design principles behind photosensitizers and drug delivery systems that depend on a singlet oxygen response or controlled release. The discussion will be accompanied by in vitro and in vivo examples, in an attempt to highlight advancements in the field and future prospects for the more widespread application of photodynamic therapy.
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