Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 373, Issue 1749, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2017.0176
Keywords
cooperativity; chaperonins; native mass spectrometry; single-molecule techniques; ring-shaped oligomers
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Funding
- US-Israel Bi-national Science Foundation [2015170]
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Advances in native mass spectrometry and single-molecule techniques have made it possible in recent years to determine the values of successive ligand binding constants for large multi-subunit proteins. Given these values, it is possible to distinguish between different allosteric mechanisms and, thus, obtain insights into how various bio-molecular machines work. Here, we describe for ring-shaped homo-oligomers, in particular, how the relationship between the values of successive ligand binding constants is diagnostic for concerted, sequential and probabilistic allosteric mechanisms. This article is part of a discussion meeting issue 'Allostery and molecular machines'.
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