Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 373, Issue 1750, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2017.0216
Keywords
pluripotent stem cells; organoids; three-dimensional culture
Categories
Funding
- NC3R SBRI CRACK-IT InMutagene award
- GSK
- Novartis
- Brunel University London Scholarship award
- UK Regenerative Medicine Platform [MRC MR/L022974/1]
- MRC [MR/L022974/1] Funding Source: UKRI
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Recent advances in the isolation of tissue-resident adult stem cells and the identification of inductive factors that efficiently direct differentiation of human pluripotent stem cells along specific lineages have facilitated the development of high-fidelity modelling of several tissues in vitro. Many of the novel approaches have employed self-organizing three-dimensional (3D) culturing of organoids, which offer several advantages over conventional two-dimensional platforms. Organoid technologies hold great promise for modelling diseases and predicting the outcome of drug responses in vitro. Here, we outline the historical background and some of the recent advances in the field of three-dimensional organoids. We also highlight some of the current limitations of these systems and discuss potential avenues to further benefit biological research using three-dimensional modelling technologies. This article is part of the theme issue 'Designer human tissue: coming to a lab near you'.
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