Journal
PHARMACOLOGY & THERAPEUTICS
Volume 181, Issue -, Pages 169-182Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2017.08.011
Keywords
Asthma; Inflammation; NF-kappa B; Toll-like receptors; Oxidative stress; Polyphenolic flavonoid compounds
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K01HL133520] Funding Source: NIH RePORTER
- NHLBI NIH HHS [K01 HL133520] Funding Source: Medline
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Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll like-receptors (TLRs) and transcription factors such as NF-kappa B, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-kappa B pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.
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