Journal
PHARMACOLOGY & THERAPEUTICS
Volume 188, Issue -, Pages 1-11Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2018.02.013
Keywords
Extracellular vesicles; Exosome biogenesis; Cargo sorting; Tumor microenvironment; Tumor-stroma communication
Categories
Funding
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [660200]
- Dutch Cancer Society [11065]
- NWO-AIMMS STAR Graduate Programme [022.005.031]
- Marie Curie Actions (MSCA) [660200] Funding Source: Marie Curie Actions (MSCA)
Ask authors/readers for more resources
Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell state and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior. (C) 2018 The Authors. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available