A mechanistic overview of herbal medicine and botanical compounds to target transcriptional factors in Breast cancer

The abnormalities of transcription factors, such as NF-kappa B, STAT, estrogen receptor, play a critical role in the initiation and progression of breast cancer. Due to the limitation of current treatment, transcription factors could be promising therapeutic targets, which have received close attention. In this review, we introduced herbal medicines, as well as botanical compounds that had been verified with anti-tumor properties via regulating transcription factors. Herbs, compounds, as well as formulae reported with various transcriptional targets, were summarized thoroughly, to provide implication for the future research on basic experiment and clinical application. (C) 2017 Elsevier Ltd. All rights reserved.