Journal
PHARMACEUTICAL CHEMISTRY JOURNAL
Volume 52, Issue 3, Pages 209-212Publisher
SPRINGER
DOI: 10.1007/s11094-018-1792-7
Keywords
glucokinase activators; N-aryl-N '-pyridin-2-ylurea
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A series of previously undescribed N-aryl-N'-pyridin-2-ylureas were prepared via the reaction of 2-aminopyridines with benzoyl azides and tested in vitro as activators of glucokinase. Statistically significant reductions of glucose levels as compared with controls were demonstrated for several compounds.
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