4.2 Article

Effects of Pharmaceutical Preparations on the Rate of Degradation of Poly(Lactide-Co-Glycolide) Scaffolds

Journal

PHARMACEUTICAL CHEMISTRY JOURNAL
Volume 52, Issue 1, Pages 69-76

Publisher

SPRINGER
DOI: 10.1007/s11094-018-1767-8

Keywords

acetylsalicylic acid; ibuprofen; 6-methyluracil; chondroitin sulfate; poly(lactide-co-glycolides); scaffolds; supercritical carbon dioxide; hydrolysis constants

Funding

  1. Russian Foundation for Basic Research [16 - 29 - 07356]

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The effects of acetylsalicylic acid, ibuprofen, 6-methyluracil, and chondroitin sulfate impregnated in poly-(lactide-co-glycolide) scaffolds of different chemical compositions and molecular weights using supercritical carbon dioxide on the processes of scaffold degradation in phosphate-buffered saline pH 7.4 were studied and the rate constants of these processes were determined. Incorporation of acetylsalicylic acid and ibuprofen into poly(lactide-co-glycolide) scaffolds was found to produce significant increases in the rate of hydrolysis of the polymer base, while the presence of methyluracil and chondroitin sulfate had virtually no effect.

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