Journal
EUROPEAN JOURNAL OF DERMATOLOGY
Volume 23, Issue 1, Pages 5-13Publisher
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ejd.2012.1884
Keywords
alopecia areata; antioxidant; autoimmune; free radicals; oxidative stress; pemphigus vulgaris; reactive oxygen species; vitiligo
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Antioxidants play the important role in our body of neutralizing free radicals and peroxides that are formed during normal physiologic events. While these reactive oxygen species are necessary for numerous biological processes, when created in excess they can have deleterious effects. The skin as an organ is constantly under attack by reactive oxygen species from both endogenous and exogenous sources. The pathophysiology of many autoimmune diseases is unknown and recently oxidative stress has come to light as a possible triggering mechanism. Recent investigations attempting to link autoimmune skin diseases and oxidative stress have had varying degrees of success. In this article, we review the current literature regarding antioxidants in alopecia areata, pemphigus vulgaris and other blistering diseases, vitiligo, and psoriasis, and suggest possible future studies and treatment options.
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