Journal
NATURE REVIEWS IMMUNOLOGY
Volume 13, Issue 6, Pages 397-411Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3452
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Funding
- US National Institutes of Health (NIH)
- Deutsche Forschungsgemeinschaft (DFG), Germany
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, USA
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Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.
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