Journal
BIOMEDICAL ENGINEERING LETTERS
Volume 3, Issue 2, Pages 67-73Publisher
SPRINGERNATURE
DOI: 10.1007/s13534-013-0097-8
Keywords
Cancer; Gold nanostructure; Photodynamic therapy; Photosensitizer; Photothermal therapy
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Funding
- National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea [1220070]
- Korea Health Promotion Institute [1220070] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Ministry of Science, ICT & Future Planning, Republic of Korea [KIOST01] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Phototherapy is a promising strategy for cancer treatment due to its selective and localized therapeutic effect by laser irradiation. Photothermal therapy damages malignant cells by using heat converted from light by an agent. On the other hand, photodynamic therapy uses photosensitizers that become cytotoxic upon irradiation with laser light at excitation wavelength. As singular treatment of each phototherapy showed some limitations, there have been significant efforts to enhance therapeutic effect by combining photothermal and photodynamic therapy. Here we review recent developments of nanoparticle platforms, in which inorganic nanostructures (photothermal therapy) are integrated with photosensitizers (photodynamic therapy) for combined phototherapeutic effect.
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