Journal
CURRENT CARDIOVASCULAR RISK REPORTS
Volume 7, Issue 3, Pages 217-223Publisher
SPRINGER
DOI: 10.1007/s12170-013-0308-y
Keywords
Maternal obesity; Gestational diabetes; Preeclampsia; Metabolic syndrome; Hypertension; Hyperlipidemia; Type II diabetes; Cardiovascular disease; Pregnancy complications
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Funding
- NICHD NIH HHS [K99 HD065786] Funding Source: Medline
- NIMHD NIH HHS [U54 MD007584] Funding Source: Medline
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Metabolic syndrome is a growing problem globally, and is a contributor to non-communicable diseases such as type II diabetes and cardiovascular disease. The risk of developing specific components of the metabolic syndrome such as obesity, hyperlipidemia, hypertension, and elevated fasting blood sugar has been largely attributed to environmental stressors including poor nutrition, lack of exercise, and smoking. However, large epidemiologic cohorts and experimental animal models support the developmental origins of adult disease hypothesis, which posits that a significant portion of the risk for adult metabolic conditions is determined by exposures occurring in the perinatal period. Maternal obesity and the rate of complications during pregnancy such as preterm birth, preeclampsia, and gestational diabetes continue to rise. As our ability to reduce perinatal morbidity and mortality improves the long-term metabolic consequences remain uncertain, pointing to the need for further research in this area.
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