Journal
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
Volume 35, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201800010
Keywords
black phosphorus; enhanced singlet oxygen production; gold nanoparticles; localized surface plasmon resonance; photodynamic therapy; photothermal therapy
Funding
- Natural Science Foundation of China [61575044]
- Joint Funds for the innovation of science and Technology of Fujian province [2016Y9062, 2015Y0056]
- Scientific Foundation of Fuzhou City [2016-S-124-3, 2015-S-143-11]
- Natural Science Foundation of Fujian Province [2016J01329, 2016J0101]
- Wu Jieping Medical Foundation [LDWJPMF-102-17007]
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Although photodynamic therapy is an efficient therapeutic strategy for cancer treatment, it always suffers from the low singlet oxygen (O-1(2)) yields owing to the weak absorption in optical transparent window of biological tissues. Herein, the black phosphorus (BP) nanosheet is integrated with gold nanoparticles (AuNPs) to simultaneously enhance the singlet oxygen generation and hyperthermia by localized surface plasmon resonance (LSPR) in cancer therapy. In the design, BP nanosheet employed as two-dimension (2D) inorganic photosensitizer is hybridized with AuNPs through polyetherimide (PEI) as bridge to form BP-PEI/AuNPs hybrid nanosheet. Such hybridation not only significantly increases the O-1(2) production of BP nanosheet through maximizing the local field enhancement of AuNPs, but also significantly enhances the light absorption of BP nanosheet to promote photothermal effect by LSPR. Accordingly, about 3.9-fold enhancement of O-1(2) production and 1.7-fold increasement of photothermal conversion efficiency are achieved compared with BP-PEI alone upon single 670 nm laser irradiation. As a proof-of-concept model, BP-PEI/AuNPs hybrid nanosheet with simultaneous dual-modal phototherapy functions result in effective suppression of tumor growth with minimized side effects both in vitro and in vivo, indicating the great potential of the BP-PEI/AuNPs hybrid nanosheet as an effective strategy to enhance the cancer therapy efficiency.
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