Journal
EUROPEAN RESPIRATORY REVIEW
Volume 22, Issue 128, Pages 131-147Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09059180.00001313
Keywords
Airway pathology; connective tissue disease; constrictive bronchiolitis; drug-induced lung disease; follicular bronchiolitis; immune deficiency
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This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.
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