Journal
NATURE REVIEWS CANCER
Volume 13, Issue 6, Pages 397-411Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3526
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Funding
- US National Cancer Institute (NCI)
- US Department of Defense (DOD) [NCI-CA161978, DOD-PR111043, NCI-CA154754]
- US National Institutes of Health (NIH)
- NCI [NCI-CA21765, NIH-EY014867, NIH-EY018599, NCI-CA168875]
- American Lebanese Syrian Associated Charities
- Howard Hughes Medical Institute Early Career Scientist Award
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Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained to developing risk-based therapies and, ultimately, improving outcome. In this Review we discuss the key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma, as well as new translational tools for bringing these promising scientific advances into the clinic.
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