Journal
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Volume 304, Issue 10, Pages F1243-F1251Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00101.2013
Keywords
epithelial cells; innate immunity; pattern recognition receptors; Toll-like receptor; endotoxin
Categories
Funding
- National Institutes of Health (NIH) [R01 DK080067]
- O'Brien Center Grant through NIH [P30DK079312]
- Dialysis Clinics, Inc.
- Veteran Affairs Merit Award
Ask authors/readers for more resources
The importance of innate immunity for survival is underscored by its presence at almost every level of the evolutionary tree of life. The task of danger recognition by the innate immune system is carried out by a broad class of pattern recognition receptors. These receptors are expressed in both hematopoietic and nonhematopoietic cells such as renal epithelial cells. Upon activation, pattern recognition receptors induce essentially two types of defensive responses: inflammation and phagocytosis. In this review, we highlight evidence that renal epithelial cells are endowed with such defensive capabilities and as such fully participate in renal innate immune responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available