Journal
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
Volume 51, Issue 2, Pages 305-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.otc.2017.11.002
Keywords
Otosclerosis; Otic capsule; Genetics; Gene; Pathophysiology
Categories
Funding
- National Institutes of Health/National Institute on Deafness and Other Communication Disorders [R01 DC05575, R01 DC01246, R01 DC012115]
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Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
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