Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 26, Issue 9, Pages 1153-1161Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2018.03.007
Keywords
Chondrocyte; Cartilage; Osteoarthritis; Bone morphogenetic proteins; Matrix metalloproteinases
Categories
Funding
- China Scholarship Council [201606370164, 201606375101]
- Provincial Science Foundation of Hunan [2015JJ3139]
- Hunan Provincial Innovation Foundation for Postgraduate [CX2016B060]
Ask authors/readers for more resources
Degeneration of articular cartilage (AC) tissue is the most common cause of osteoarthritis (OA) and rheumatoid arthritis. Bone morphogenetic proteins (BMPs) play important roles in bone and cartilage formation. This article reviews the experimental and clinical applications of BMPs in cartilage regeneration. Experimental evidence indicates that BMPs play an important role in protection against cartilage damage caused by inflammation or trauma, by binding to different receptor combinations and, consequently, activating different intracellular signaling pathways. Loss of function of BMP-related receptors contributes to the decreased intrinsic repair capacity of damaged cartilage and, thus, the multifunctional effects of BMPs make them attractive tools for the treatment of cartilage damage in patients with degenerative diseases. However, the development of BMP therapy as a treatment modality for cartilage regeneration has been hampered by certain factors, such as the eligibility of participants in clinical trials, financial support, drug delivery carrier safety, availabilities of effective scaffolds, appropriate selection of optimal dose and timing of administration, and side effects. Further research is needed to overcome these issues for future routine clinical applications. Research and development leading to the successful application of BMPs can initiate a new era in the treatment of cartilage degenerative diseases like OA. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available