Journal
ORGANIC LETTERS
Volume 20, Issue 15, Pages 4579-4583Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01866
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Funding
- National Natural Science Foundation of China [81673297]
- Shanghai Municipal Committee of Science and Technology [17JC1400200, 17431902500]
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An efficient and mild zinc-mediated decarboxylative alkylation of gem-difluoroalkenes with N-hydroxyphthalimide (NHP) esters, to give monofluoroalkenes in moderate to excellent yields with high Z-selectivity is reported. The reaction tolerates a broad range of functional groups and can be easily scaled up, which thus may pave the way for its further applications in medicinal chemistry and materials science.
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