Iron-Catalyzed Decarboxylative Olefination of Cycloketone Oxime Esters with alpha,beta-Unsaturated Carboxylic Acids via C-C Bond Cleavage

An iron-catalyzed redox-neutral, decarboxylative olefination of cycloketone oxime esters with alpha,beta-unsaturated carboxylic acids has been developed. This reaction involves an iminyl radical mediated C-C bond cleavage/radical addition/decarboxylation cascade. This protocol is highlighted by its low-cost catalytic system and readily accessible starting materials, as well as broad substrate scope, thus providing facile access to structurally diverse cyano-containing alkenes.