Journal
ORGANIC LETTERS
Volume 20, Issue 4, Pages 1034-1037Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03984
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Funding
- Natural Science Basic Research Plan in Shaanxi Province of China [2016JZ002]
- National Natural Science Foundation of China [21602168]
- Fundamental Research Funds of the Central Universities [zrzd2017001, xjj2016056, 1191329724]
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An efficient synthesis of cyanoalkylated heteroarenes via iron-catalyzed direct C-H cyanoalkylation of heteroarenes has been developed. Structurally diverse cyanoalkyl motifs generated through C-C bond cleavage of cyclobutanone oxime esters have been introduced into quinoxalin-2(1H)-ones, flavone, benzothiazoles, and caffeine in good to excellent yields. Remarkably, less-strained cyclopentanone and unstrained cyclohexanone oxime esters were also amenable substrates in this cyanoalkylation reaction.
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