Journal
ORGANIC LETTERS
Volume 20, Issue 15, Pages 4536-4539Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01744
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Funding
- National Natural Science Foundation of China [21625205, 21332003]
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An efficient asymmetric intramolecular trapping of ammonium ylides of alpha-diazoketones with enones to synthesize indoline derivatives was realized. A Rh(II)/chiral N,N'-dioxide-Sc(III) complex bimetallic relay catalytic system was established. A series of optically active 2,2,3-trisubstituted indolines were obtained in high yields (up to 99%), good enantioselectivities (up to 99% ee), and excellent diastereoselectivities (up to >19:1 dr) under mild reaction conditions.
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