4.8 Article

Direct Dehydrogenative Arylation of Benzaldehydes with Arenes Using Transient Directing Groups

Journal

ORGANIC LETTERS
Volume 20, Issue 7, Pages 1794-1797

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00292

Keywords

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Funding

  1. National Natural Science Foundation of China [NSFC-21572178, NSFC-21702162]
  2. Natural Science Basic Research Plan in Shaanxi Province of China [2017JM2006]
  3. Key Science and Technology Innovation Team of Shaanxi Province [2017KCT-37]
  4. Scientific Research Program - Shaanxi Provincial Education Department [17JK0788]

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The utilization of the transient directing strategy into the direct oxidative dehydrogenative arylation of aldehydes with arenes was reported for the first time. Featured by mild reaction conditions, good functional group compatibility, and great regioselectivity, the method should find broad applications in new medicine and material development and discovery processes.

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