Journal
ORGANIC LETTERS
Volume 20, Issue 15, Pages 4549-4553Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01848
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Funding
- National Natural Science Foundation of China [81730093]
- CAMS Innovation Fund for Medical Sciences [2016-I2M-2-003, 2017-I2M-2-010]
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Three triterpene saponins, nototronesides A-C (1-3), possessing an unprecedented 6/6/9 fused tricyclic tetranordammarane core, were isolated from the leaves of Panax notoginseng. Their structures were elucidated on the basis of spectroscopic data, and the structure of sapogenin (1a) was further confirmed by X-ray crystallography. The existence of 1-3 adds a new dimension to the diversity of the triterpene family. Moreover, compound 2 showed a moderate neuroprotective effect on serum deficiency-induced cellular damage in PC12 cells.
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