4.8 Article

Copper-Catalyzed Radical Difluoroalkylation and Redox Annulation of Nitroalkynes for the Construction of C2-Tetrasubstituted Indolin-3-ones

Journal

ORGANIC LETTERS
Volume 20, Issue 2, Pages 393-396

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03678

Keywords

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Funding

  1. Recruitment Program of Global Experts (1000 Talents Plan)
  2. Natural Science Foundation of Fujian Province [2016J01064]
  3. Fujian Hundred Talents Plan
  4. Program of Innovative Research Team of Huaqiao University [Z14X0047]
  5. Subsidized Project for Cultivating Postgraduates' Innovative Ability in Scientific Research of Huaqiao University

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An efficient and convenient method with wide applicability for the synthesis of C2-tetrasubstituted indolin-3-ones via copper-catalyzed redox cycloisomerization of nonprefunctionalized nitroalkynes has been developed. This protocol features simple operation, readily available starting materials, good functional group tolerace, broad scope, and diboron as the reductant.

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