4.8 Article

Cu-Catalyzed Electrophilic Disulfur Transfer: Synthesis of Unsymmetrical Disulfides

Journal

ORGANIC LETTERS
Volume 20, Issue 13, Pages 3829-3832

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01418

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Funding

  1. Natural Science Foundation of China [21572118, JQ201505]
  2. Natural Science Foundation of Shandong Province [21572118, JQ201505]
  3. Shandong University

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An efficient electrophilic persulfuration reaction leading to unsymmetrical disulfides and polysulfides has been developed. Various nucleophiles, including aryl boronic acids, beta-keto esters, and thiols, can be used as substrates. The notable features of this method include very simple and practical conditions, general scope, and inexpensive copper catalysts.

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