Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to beta-Amino Alcohols

A new Passerini-type reaction in which hexafluoroisopropanol functions as the acid component is reported. The reaction tolerates a broad range of isocyanides and aldehydes, and the formed imidates can be reduced toward beta-amino alcohols under mild and metal-free conditions. In addition, the imidate products were shown to undergo an unprecedented retro-Passerini-type reaction under information about the Passerini reaction and its variations. microwave conditions, providing valuable mechanistic