Journal
ORGANIC LETTERS
Volume 20, Issue 13, Pages 3866-3870Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01449
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The use of methanol for the selective methylation of aromatic amines with RuHCl(CO)((PNP)-P-H) ((PNP)-P-H = bis(2-diphenylphosphinoethyl)amine) is reported. Various aromatic amines were transformed into their corresponding monomethylated secondary amines in high yields at 150 degrees C with a very low catalyst loading (0.02-0.1 mol %) in the presence of (KOBu)-Bu-t (20-60 mol %). The catalyst precursor, RuHCl(CO)((PNP)-P-H), was converted to [RuH(CO)(2)((PNP)-P-H)](+) under the catalytic conditions and also serves as a highly effective catalyst. The robustness of this catalyst contributes to its outstanding catalytic activity, even under reaction conditions, in which CO is liberated from methanol.
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