Journal
ORGANIC LETTERS
Volume 20, Issue 6, Pages 1534-1537Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00260
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Funding
- National Natural Science Foundation of China [21672086]
- Gansu Province Science Foundation [1606RJYA260]
- Fundamental Research Funds for the Central Universities [lzujbky-2018-39]
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The strategy for the synthesis of C2-substituted indoles and quinolines from 2-vinylanilines and alkynoates through C-C bond cleavage is developed. With these general methods, 2-substituted indoles and quinolines can be accessed via tandem Michael addition and cyclization with no requirement of oxidant. This strategy not only provides a method for the synthesis C2-substituted indoles in good yields through the simultaneous cleavage of C = C and C equivalent to C bonds under metal-free conditions but also provides a simple method for the generation of the C2-substituted quinolines in moderate yields via Pd-catalyzed C equivalent to C bond cleavage.
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