Journal
ORGANIC LETTERS
Volume 20, Issue 8, Pages 2208-2212Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00538
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Funding
- National Natural Science Foundation of China [21790333, 21702197, 21672199]
- CAS Interdisciplinary Innovation Team
- Fundamental Research Funds for the Central Universities
- Anhui Provincial Natural Science Foundation [1708085MB28]
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An efficient palladium-catalyzed hydrocarbonylative C-N coupling of alkenes with amides has been developed. The reaction was performed via hydrocarbonylation of alkenes, followed by acyl metathesis with amides. Both intermolecular and intramolecular reactions proceed smoothly to give either branched or linear amides in high turnover number (3500) with NH4Cl or NMP center dot HCl as a proton source under the palladium catalysis. This reaction offers a catalytic convenient approach to deuterated amides when inexpensive NMP center dot DCl served as a deuterium source.
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