4.8 Article

Copper(I)-Catalyzed Three-Component Click/Persulfuration Cascade: Regioselective Synthesis of Triazole Disulfides

Journal

ORGANIC LETTERS
Volume 20, Issue 10, Pages 2956-2959

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01002

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Funding

  1. National Natural Science Foundation of China [21572118, JQ201505]
  2. National Natural Science Foundation of Shandong Province [21572118, JQ201505]
  3. Shandong University

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A copper(I)-catalyzed three-component CuAAC/persulfuration reaction providing rapid access to asymmetric triazole disulfides has been developed. The interrupted click reaction shows broad substrate scope, complete regioselectivity, and excellent functional group tolerability.

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