Journal
ORGANIC LETTERS
Volume 20, Issue 10, Pages 3065-3069Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01099
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Funding
- Chinese NSF [81430080, 81773565]
- National Program on Key Basic Research Project of China [2015CB910603]
- International Cooperative Program of the Chinese Academy of Sciences [GJHZ1622]
- Key Program of the Frontier Science of the Chinese Academy of Sciences [QYZDJ-SSW-SMC002]
- Shanghai Commission of Science and Technology [16XD1404600]
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An Rh(III)-catalyzed C-H activation of pyrazolones with 1,6-enynes was investigated. The regioselectivity of the C-H activation/alkyne insertion is readily solved by using symmetric enyne coupling partners, and a C-H activation-triggered cascade reaction is realized, which involves alkyne insertion, tautomerization, and double cyclization to offer a class of structurally complex polycyclic architectures. This cascade reaction tolerates a broad substrate scope in high regioselectivity and stereospecificity and furnishes three new chemical bonds and four chiral centers in a single operation. Various derivatizations of the polycyclic scaffolds are conducted, providing products with ample space for further functional transformations.
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